5AM Venture Management, LLC - Stock Holdings in 13F Filings (SEC)

Updated on March 15, 2026.

Based on 13F Filings filed with the SEC on February 17, 2026, for the 2025 Q4 period, 5AM Venture Management, LLC held in its portfolio 21 assets valued at $318,102,880 (i.e. $318.10M).

The most valuable assets in the portfolio included: ENTRADA THERAPEUTICS INC ($41.70M), CAMP4 THERAPEUTICS CORP ($35.98M), and TYRA BIOSCIENCES INC ($27.06M).

The chart below shows the top 10 valuable assets, and the table below shows the top 21 valuable assets.

You can see similar for other investment managers.

Related Topics: SEC Topic List.

Data Source: SEC.

Top Valuable Stocks in 5AM Venture Management, LLC Portfolio

ENTRADA THERAPEUTICS INC

CAMP4 THERAPEUTICS CORP

TYRA BIOSCIENCES INC

VIRIDIAN THERAPEUTICS INC

PHARVARIS N V

ERASCA INC

EYEPOINT INC

MAPLIGHT THERAPEUTICS INC

CENTESSA PHARMACEUTICALS PLC

CELLDEX THERAPEUTICS INC NEW

5AM Venture Management, LLC - Stock Holdings in 13F Filings (SEC)

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Name of Issuer	No. of Shares	Value ($)	Class
ENTRADA THERAPEUTICS INC	4056379	41699576	COM
CAMP4 THERAPEUTICS CORP	5869091	35977528	COM
TYRA BIOSCIENCES INC	1029298	27060244	COM
VIRIDIAN THERAPEUTICS INC	736595	22922836	COM
PHARVARIS N V	797600	22133400	COM
ERASCA INC	5405404	20108103	COM
EYEPOINT INC	1050000	19183500	COM NEW
MAPLIGHT THERAPEUTICS INC	950011	16686943	COM
CENTESSA PHARMACEUTICALS PLC	580945	14529434	SPONSORED ADS
CELLDEX THERAPEUTICS INC NEW	497270	13505853	COM NEW
TECTONIC THERAPEUTIC INC	606660	12654928	COM
ENLIVEN THERAPEUTICS INC	772477	11896146	COM
ARTIVA BIOTHERAPEUTICS INC	2353304	10095674	COM
SURROZEN INC	387500	8757500	COM NEW
BIOHAVEN LTD	738972	8342994	COM
PROTARA THERAPEUTICS INC	1369782	7300938	COM STK
GH RESEARCH PLC	572665	7272846	ORDINARY SHARES
SKYE BIOSCIENCE INC	9681763	7258418	COM NEW
ZENTALIS PHARMACEUTICALS INC	3947913	5329683	COM
SILENCE THERAPEUTICS PLC	476200	2895296	ADS
RALLYBIO CORP	3630724	2491040	COM