US Number and Rate of Fatal Drug Overdose Deaths Involving Illegally-made Fentanyls By State in 2021 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Illegally-made Fentanyls in the US in 2021 was 37,477, and the age adjusted rate per 100,000 persons was 25.1. These overall values was based on data from 33 jurisdictions (i.e. states and DC).

Among all states with data, Ohio had the highest number of fatal drug overdose deaths involving Illegally-made Fentanyls (4,340), followed by Pennsylvania (4,173), North Carolina (3,025), and New Jersey (2,604).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Illegally-made Fentanyls per 100K persons, West Virginia had the highest (69.4), followed by Delaware (45), and Kentucky (40.2).

The interactive chart below shows the number of fatal overdose deaths involving Illegally-made Fentanyls by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Illegally-made Fentanyls By State in 2021 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Illegally-made Fentanyls By State in 2021
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 155 21.4
Arizona 1786 25.5
Arkansas 377 13.1
Colorado 974 16.3
Connecticut 1314 36.9
Delaware 428 45
Georgia 1363 12.7
Hawaii 44 3.1
Iowa 199 6.6
Kansas 339 12.1
Kentucky 1728 40.2
Maine 483 37
Maryland 2348 37.8
Massachusetts 2149 30.8
Michigan 2255 23.1
Minnesota 922 16.8
Nebraska 88 4.8
Nevada 311 9.9
New Hampshire 349 25.6
New Jersey 2604 28.1
New Mexico 584 28.9
North Carolina 3025 29.5
Ohio 4340 38.6
Oklahoma 309 8
Oregon 516 12.3
Pennsylvania 4173 33.4
Rhode Island 337 31.3
South Dakota 27 3.3
Utah 166 5
Vermont 207 34.5
Virginia 2025 23.6
West Virginia 1152 69.4
District of Columbia 400 63.5