US Number and Rate of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2021 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Any Opioids in the US in 2021 was 42,293, and the age adjusted rate per 100,000 persons was 28.2. These overall values was based on data from 33 jurisdictions (i.e. states and DC).

Among all states with data, Ohio had the highest number of fatal drug overdose deaths involving Any Opioids (4,640), followed by Pennsylvania (4,538), North Carolina (3,333), and New Jersey (2,799).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Any Opioids per 100K persons, West Virginia had the highest (74.9), followed by Delaware (49), and Kentucky (45.1).

The interactive chart below shows the number of fatal overdose deaths involving Any Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2021 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2021
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 216 29.7
Arizona 1996 28.4
Arkansas 466 16.2
Colorado 1300 21.7
Connecticut 1418 39.7
Delaware 466 49
Georgia 1715 15.9
Hawaii 77 5.4
Iowa 239 7.9
Kansas 431 15.4
Kentucky 1948 45.1
Maine 546 41.5
Maryland 2515 40.5
Massachusetts 2281 32.7
Michigan 2499 25.6
Minnesota 1017 18.5
Nebraska 112 6.1
Nevada 545 17.2
New Hampshire 378 27.7
New Jersey 2799 30.2
New Mexico 731 36.3
North Carolina 3333 32.5
Ohio 4640 41.2
Oklahoma 438 11.4
Oregon 738 17.4
Pennsylvania 4538 36.2
Rhode Island 383 35.5
South Dakota 35 4.3
Utah 412 12.9
Vermont 220 36.6
Virginia 2191 25.6
West Virginia 1246 74.9
District of Columbia 424 67.6