US Number and Rate of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2022 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Any Opioids in the US in 2022 was 47,454, and the age adjusted rate per 100,000 persons was 28.7. These overall values was based on data from 35 jurisdictions (i.e. states and DC).

Among all states with data, Ohio had the highest number of fatal drug overdose deaths involving Any Opioids (4,365), followed by Pennsylvania (4,358), North Carolina (3,572), and Illinois (3,073).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Any Opioids per 100K persons, West Virginia had the highest (72.1), followed by Delaware (50.6), and Maine (46.8).

The interactive chart below shows the number of fatal overdose deaths involving Any Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2022 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Any Opioids By State in 2022
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 190 25.8
Arizona 1959 27.7
Arkansas 362 12.6
Colorado 1201 19.8
Connecticut 1348 37.2
Delaware 491 50.6
Georgia 1904 17.6
Hawaii 97 6.9
Illinois 3073 24.6
Iowa 211 7.1
Kansas 488 17.3
Kentucky 1836 42.5
Maine 617 46.8
Maryland 2255 36.4
Massachusetts 2360 33.7
Minnesota 1029 18.6
Mississippi 484 17.4
Missouri 1551 26
Montana 112 10.4
Nebraska 120 6.4
New Hampshire 424 31
New Jersey 2827 30.5
New Mexico 680 33.8
North Carolina 3572 34.4
Ohio 4365 38.7
Oklahoma 750 19.3
Oregon 956 22.5
Pennsylvania 4358 34.9
Rhode Island 358 33.3
Tennessee 3065 44.7
Utah 416 13.2
Vermont 236 39.3
Virginia 2104 24.5
West Virginia 1198 72.1
District of Columbia 457 72.6