US Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2021 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Prescription Opioids in the US in 2021 was 8,199, and the age adjusted rate per 100,000 persons was 5.4. These overall values was based on data from 33 jurisdictions (i.e. states and DC).

Among all states with data, Pennsylvania had the highest number of fatal drug overdose deaths involving Prescription Opioids (919), followed by Ohio (557), North Carolina (528), and New Jersey (484).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Prescription Opioids per 100K persons, West Virginia had the highest (18.1), followed by New Mexico (12.8), and Maine (10.8).

The interactive chart below shows the number of fatal overdose deaths involving Prescription Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2021 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2021
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 69 9.5
Arizona 260 3.6
Arkansas 143 5
Colorado 385 6.4
Connecticut 303 8.3
Delaware 70 7.2
Georgia 384 3.6
Hawaii 23 1.6
Iowa 55 1.7
Kansas 103 3.7
Kentucky 437 9.9
Maine 150 10.8
Maryland 458 7.2
Massachusetts 457 6.5
Michigan 405 4
Minnesota 179 3.2
Nebraska 32 1.8
Nevada 170 5.2
New Hampshire 40 2.9
New Jersey 484 5.2
New Mexico 256 12.8
North Carolina 528 5.2
Ohio 557 4.9
Oklahoma 123 3.2
Oregon 109 2.5
Pennsylvania 919 7.2
Rhode Island 109 10
South Dakota 10 9999
Utah 160 5.4
Vermont 40 6.6
Virginia 417 4.9
West Virginia 305 18.1
District of Columbia 59 9.5