US Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2022 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Prescription Opioids in the US in 2022 was 7,443, and the age adjusted rate per 100,000 persons was 4.5. These overall values was based on data from 35 jurisdictions (i.e. states and DC).

Among all states with data, Pennsylvania had the highest number of fatal drug overdose deaths involving Prescription Opioids (767), followed by North Carolina (477), Massachusetts (460), and Ohio (451).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Prescription Opioids per 100K persons, West Virginia had the highest (14.8), followed by Maine (11.5), and Rhode Island (8).

The interactive chart below shows the number of fatal overdose deaths involving Prescription Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2022 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2022
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 43 6.1
Arizona 221 3.1
Arkansas 98 3.4
Colorado 276 4.6
Connecticut 273 7.3
Delaware 52 5.3
Georgia 372 3.4
Hawaii 24 1.6
Illinois 417 3.3
Iowa 34 1.1
Kansas 97 3.4
Kentucky 280 6.3
Maine 153 11.5
Maryland 348 5.5
Massachusetts 460 6.5
Minnesota 157 2.9
Mississippi 78 2.7
Missouri 173 2.8
Montana 32 3
Nebraska 28 1.5
New Hampshire 24 1.6
New Jersey 385 4.1
New Mexico 153 7.5
North Carolina 477 4.6
Ohio 451 3.9
Oklahoma 129 3.4
Oregon 95 2.2
Pennsylvania 767 6.1
Rhode Island 87 8
Tennessee 444 6.4
Utah 169 5.6
Vermont 44 7.5
Virginia 290 3.4
West Virginia 254 14.8
District of Columbia 58 9.5