US Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2024 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Prescription Opioids in the US in 2024 was 7,301, and the age adjusted rate per 100,000 persons was 3.3. These overall values was based on data from 43 jurisdictions (i.e. states and DC).

Among all states with data, New York had the highest number of fatal drug overdose deaths involving Prescription Opioids (738), followed by Pennsylvania (546), Ohio (369), and Illinois (333).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Prescription Opioids per 100K persons, West Virginia had the highest (8.8), followed by Rhode Island (6.4), and New Mexico (6.2).

The interactive chart below shows the number of fatal overdose deaths involving Prescription Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2024 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2024
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State Number of Deaths Age Adjusted Rate Per 100K
Alaska 37 5
Arizona 291 3.9
Arkansas 58 1.9
Colorado 228 3.7
Connecticut 219 5.8
Delaware 50 4.9
Georgia 262 2.3
Hawaii 22 1.4
Illinois 333 2.6
Indiana 160 2.4
Iowa 44 1.5
Kansas 75 2.7
Kentucky 220 4.9
Maine 72 5.2
Maryland 298 4.6
Massachusetts 310 4.3
Michigan 218 2.1
Minnesota 96 1.7
Mississippi 40 1.4
Missouri 124 2
Montana 27 2.4
Nebraska 23 1.2
Nevada 130 3.8
New Hampshire 23 1.5
New Jersey 280 2.9
New Mexico 128 6.2
New York 738 3.6
Ohio 369 3.2
Oklahoma 93 2.3
Oregon 128 2.9
Pennsylvania 546 4.2
Rhode Island 70 6.4
South Carolina 179 3.3
South Dakota 10 9999
Tennessee 278 3.9
Utah 163 5.2
Vermont 38 6.1
Virginia 212 2.4
Washington 301 3.7
West Virginia 150 8.8
Wisconsin 193 3.3
Wyoming 27 4.5
District of Columbia 38 6