US Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2023 (CDC)

Updated on February 2, 2026.

Based on data from the CDC, the overall number of fatal drug overdose deaths involving Prescription Opioids in the US in 2023 was 9,267, and the age adjusted rate per 100,000 persons was 4.1. These overall values was based on data from 42 jurisdictions (i.e. states and DC).

Among all states with data, New York had the highest number of fatal drug overdose deaths involving Prescription Opioids (1,081), followed by Pennsylvania (730), North Carolina (509), and Ohio (451).

In terms of the age-adjusted rate of fatal drug overdose deaths involving Prescription Opioids per 100K persons, West Virginia had the highest (12), followed by Rhode Island (7.7), and New Mexico (7.6).

The interactive chart below shows the number of fatal overdose deaths involving Prescription Opioids by state for the jurisdictions with d ata. The table below shows the number and rate of fatal drug overdose deaths.

You can also see similar information for other types of drugs.

Note: A rate value of 9999 denotes that the value is suppressed. Rates based on less than 20 drug overdose deaths are suppressed to avoid presentation of unstable rates.

Related Topics: US CDC Topic List
Data Source: CDC (SUDORS).
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Number of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2023 (CDC)
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Number and Rate of Fatal Drug Overdose Deaths Involving Prescription Opioids By State in 2023
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State Number of Deaths Age Adjusted Rate Per 100K
Alabama 146 2.9
Alaska 43 6
Arizona 241 3.3
Arkansas 90 3.1
Colorado 231 3.9
Connecticut 269 7.2
Delaware 59 5.9
Georgia 312 2.8
Hawaii 22 1.4
Illinois 386 3
Indiana 186 2.8
Iowa 45 1.4
Kansas 72 2.5
Kentucky 300 6.8
Maine 101 7.4
Maryland 314 5.1
Massachusetts 418 5.9
Michigan 228 2.2
Minnesota 107 1.9
Mississippi 71 2.5
Missouri 156 2.6
Montana 27 2.5
Nebraska 23 1.2
Nevada 144 4.3
New Hampshire 24 1.5
New Jersey 362 3.8
New Mexico 154 7.6
New York 1081 5.4
North Carolina 509 4.8
Ohio 451 4
Oklahoma 111 2.8
Oregon 113 2.6
Pennsylvania 730 5.6
Rhode Island 85 7.7
Tennessee 387 5.5
Utah 173 5.7
Vermont 41 6.7
Virginia 223 2.6
Washington 319 4
West Virginia 204 12
Wisconsin 253 4.4
District of Columbia 56 8.8